Award winner
Active Serum
The all-rounder — softens lines, evens tone and keeps breakouts down at the same time.
Anti-agingAnti-acneicResurfacing
From €103
· 15ml · 30ml
Compare the range
Find your serum
Every iS Clinical serum is built around a different job — resurfacing, protecting, calming, hydrating, brightening. Filter by what your skin is actually doing, then compare formulas side by side.
A note on the glass
Cobalt and amber bottles aren't styling. Both block the light that degrades active Vitamin C and Retinol — amber is used where the formula is most light-sensitive.
Filter by concern
The serum range
Tick VS on up to three to see them head to head.
Most advanced
GeneXC Serum
Daytime defence — the highest Vitamin C in the range, built for environmental damage.
ProtectiveRegenerativeAge-defying
From €123
· 15ml · 30ml
Pro-Heal Serum Advance+
Reactive, compromised or breakout-prone skin that needs calming as well as correcting.
HealingSuper antioxidant
From €111
· 15ml · 30ml
Brightening Serum
Dark marks, melasma and uneven tone — used all over, or spot-applied to problem areas.
Targeted brighteningSafe lightening
From €97
· 15ml · 30ml
Highest rated
Hydra-Cool Serum
Instant hydration and relief for skin that feels hot, tight, stripped or irritated.
HydratingSoothingAnti-acneic
From €75
· 15ml · 30ml
Poly-Vitamin Serum
Dry, depleted skin that needs feeding as well as watering — texture, tone and resilience.
RevitalizingHydratingAnti-ageing
From €84
· 15ml · 30ml
Eye area
C Eye Serum Advance+
Fine lines, puffiness and dark circles on the thinner skin around the eye.
RevitalizingHydratingAnti-aging
€79
No serum targets that on its own — try another concern, or show all.
Head to head
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Full comparison
Formulation detail across the range. Ingredients and skin-type guidance come from each product's own specification.
| Serum |  Active Serum
From €103
|  GeneXC Serum
From €123
|  Pro-Heal Serum Advance+
From €111
|  Brightening Serum
From €97
|  Hydra-Cool Serum
From €75
|  Poly-Vitamin Serum
From €84
|  C Eye Serum Advance+
€79
|
|---|---|---|---|---|---|---|---|
| Best for | The all-rounder — softens lines, evens tone and keeps breakouts down at the same time. | Daytime defence — the highest Vitamin C in the range, built for environmental damage. | Reactive, compromised or breakout-prone skin that needs calming as well as correcting. | Dark marks, melasma and uneven tone — used all over, or spot-applied to problem areas. | Instant hydration and relief for skin that feels hot, tight, stripped or irritated. | Dry, depleted skin that needs feeding as well as watering — texture, tone and resilience. | Fine lines, puffiness and dark circles on the thinner skin around the eye. |
| Key benefits | Anti-aging · Anti-acneic · Resurfacing | Protective · Regenerative · Age-defying | Healing · Super antioxidant | Targeted brightening · Safe lightening | Hydrating · Soothing · Anti-acneic | Revitalizing · Hydrating · Anti-ageing | Revitalizing · Hydrating · Anti-aging |
| Hero ingredients | Sugar Cane (Glycolic), Willow Bark (Salicylic), Bilberry (Lactic), Arbutin, Mushroom Extract (Kojic) | 20% L-Ascorbic Acid, Extremozymes (Trehalose, Synechococcus, Plankton), Kakadu Plum, Superoxide Dismutase, Mixed Fruit Acids | L-Ascorbic Acid (Vitamin C), Olive Leaf Extract, Vitamin E, Vitamin A (Retinol), Zinc Sulfate | Arbutin, Mushroom Extract (Kojic), Willow Bark (Salicylic), Sugar Cane (Glycolic), Bilberry (Lactic), Norwegian Kelp | Hyaluronic Acid, Centella Asiatica, Vitamin B5 (Pantothenic Acid), Menthol | Hyaluronic Acid, Niacinamide, Retinol, Vitamin E, Green Tea, Vitamin B5, Zinc | 7.5% L-Ascorbic Acid, Copper Tripeptide-1, Hyaluronic Acid, Zinc Sulphate |
| Suits | Ageing skin · Acne prone skin · Hyperpigmented skin · Sun damaged skin | DNA Repair | All skin types - Rosacea, Acne, Insect bites & Contact dermatitis | Hyperpigmentation | Dry/Dehydrated skin · Irritated skin · Acneic skin · Sunburned skin · Sensitive skin · Post shaving | Dry skin | Eye ageing |
| Texture & feel | Lightweight fluid, absorbs in seconds. Expect a distinct cooling tingle for a minute after applying. | Fluid and fast-absorbing, leaves skin smooth rather than filmy. Sits well under SPF. | Silky and slightly viscous with a faint vitamin scent. Settles without tackiness. | Lightweight and quick to absorb. Exfoliates steadily without visible peeling. | Watery gel that cools on contact. Gentle enough for daily use on the most sensitive skin. | Richer and more cushioning than Hydra-Cool. Layers neatly under a night moisturiser. | Light serum that absorbs without heaviness, so makeup goes over it cleanly. |
| Strength | Very active | Very active | Active | Active | Gentle | Moderate | Gentle |
| When to use | Morning and night | Morning, under SPF | Morning or night | Morning and night | Morning and night | Night — contains Retinol | Morning and night |
| Where it layers | Step 2 — treatment | Step 2 — treatment | Step 2 — treatment | Step 2 — treatment, or spot-applied | Step 3 — support | Step 3 — support | Step 4 — eye area |
| Sizes | 15ml · 30ml | 15ml · 30ml | 15ml · 30ml | 15ml · 30ml | 15ml · 30ml | 15ml · 30ml | — |
| Price | €103 – €166 | €123 – €199 | €111 – €185 | €97 – €162 | €75 – €116 | €84 – €134 | €79 |
| Rating | ★ 4.88 / 5 · 8 reviews | — | ★ 4.84 / 5 · 19 reviews | — | ★ 5.0 / 5 · 16 reviews | — | — |
Layering them together
Thinnest and most active first, richest last — one treatment serum and one support serum is plenty for most skins.
01 · Cleanse
Start on clean, damp skin
Actives absorb better on skin that is still slightly damp. Pat, don't rub dry.
02 · Treat
One treatment serum
The serum doing the heavy lifting on your main concern — Active, GeneXC, Pro-Heal Advance+ or Brightening. One is enough.
03 · Support
Hydrate and buffer
Hydra-Cool or Poly-Vitamin, layered over the treatment serum to cushion it and hold water in.
04 · Eyes
Around the orbital bone
C Eye Serum Advance+ goes on before moisturiser, patted along the bone rather than right up to the lash line.
05 · Seal
Moisturiser, then SPF
Daily SPF is non-negotiable with any resurfacing or brightening serum — it protects the results you are paying for.
Ratings are verified customer reviews collected on this site and update automatically. Strength ratings are a guide to how active a formula feels in use, not a clinical measure. Always patch test when introducing a new active. If you are pregnant, breastfeeding or under the care of a dermatologist, check with your clinician before starting a Retinol- or acid-containing formula.